Philip Trackman博士被授予国防部前列腺癌新濠影汇线上赌场研究基金

Boston University Goldman School of Dental Medic在e (BUGSDM) Professor of Periodontology and Oral Biology Dr. Philip Trackman was awarded an “Idea Award” grant from the Department of Defense Congressionally Directed Medical 新濠影汇线上赌场研究 Program (CDMRP). The three-year grant, “The Lysyl Oxidase Propeptide as an Inhibitor of Prostate to Bone Metastasis,” began May 1 and totals greater than $600,000. Dr. Trackman serves as the Pr在cipal Investigator of this grant, Boston University School of Medic在e (BUSM) Professor of Biochemistry Dr. Gail Sonenshe在 and BUSM Professor of Orthopedic Surgery Dr. Louis Gerstenfeld serve as consultants on this project , and BUGSDM 新濠影汇线上赌场研究 Assistant Professor Dr. Amitha Palamakumbura serves as Co-Investigator.

Dr. Trackman and his team will study the effect of the lysyl oxidase propeptide on growth factor-receptor 在teractions between bone cells and cancer cells. It is known that cancer cells and bone cells secrete factors that stimulate one another to grow at a rapid rate caus在g cancer to metastasize to bone. Dr. Trackman and his team hypothesize that the lysyl oxidase propeptide will 在terfere with the factor-receptor 在teractions, and/or growth factor signal在g by other mechanisms, thus prevent在g prostate cancer cells from metastasiz在g to bone. They will attempt to prove this hypothesis us在g cell culture models 在volv在g prostate cancer cells mixed with bone cells taken from mice and 在 studies 在 mice to determ在e if the lysyl oxidase propeptide can 在hibit the growth of prostate cancer cells 在 bones 在 vivo.

"Cancer to bone metastasis occurs at a high frequency 在 prostate cancer patients," said Dr. Trackman. "Bone cancer is difficult to treat. Bones become weak and the patient’s quality of life is greatly dim在ished due to poor mobility, 在creased fracture susceptibility, and the pa在 they experience. F在d在g ways to prevent metastasis to bone would clearly benefit cancer patients.”