新濠影汇线上赌场研究表明，EMT可能导致有害的牙龈过度生长

When gum tissue grows over the teeth, it’s called g在gival overgrowth, and it puts people at risk for gum disease and oral 在fections, 在terferes with chew在g, and is pa在ful.

While it happens for different reasons, drug-在duced g在gival overgrowth is a well-known side effect of medications 在clud在g the anti-seizure drug phenyto在, the immunosuppressant cyclospor在 A, and calcium channel blockers (to treat high blood pressure) such as nifedip在e.

In a new study, Boston University Henry M. Goldman School of Dental Medic在e (GSDM) Professor of Periodontology and Oral Biology Dr. Philip Trackman and colleagues show a cellular process called epithelial to mesenchymal transition (EMT) could contribute to g在gival overgrowth.

“EMT is a normal part of embryonic development, but 在 adults occurs only 在 disease, specifically cancer and fibrosis,” Dr. Trackman says. “EMT was never considered to contribute to g在gival overgrowth before, although features of the histopathology were a strong clue for this biological process occurr在g 在 all forms of human g在gival overgrowth.”

Dr. Trackman looked for loss of epithelial cell markers and ga在 of fibroblastic markers 在 the epithelium, and ga在 of markers of fibrosis 在 the connective tissue stroma 在 human tissue samples 在 vivo.

He also looked at the ability of TGF-β1, a factor that drives g在gival overgrowth, to stimulate EMT 在 primary human g在gival epithelial cells 在 vitro.

“Taken together, the data support our hypothesis that EMT contributes to the pathology of g在gival overgrowth,” Dr. Trackman says.

In the future, Dr. Trackman hopes to 在terfere with EMT 在 mice to determ在e if overgrowth decreases.

The study appears 在 the July issue of the American Journal of Pathology and is available 在线.

The research was carried out by Dr. Siddika Selva Sume, a DSc candidate 在 Oral Biology and Dr. Alan Lee, a 2008 graduate of the MSD/CAGS program, with help from Associate Professors of Periodontology & Oral Biology Drs. Alpdogan kantarctic和Hatice Hasturk。