Gerhard Stock to give May 4 CCS Seminar, “Energy and Signal Flow in Biomolecules”

May 4, 2016
12 noon (with lunch)
Physics Research Building, Room 595
3 Cummington Mall

Energy and Signal Flow in Biomolecules

Professor Gerhard Stock
Biomolecular Dynamics, Institute of Physics
Albert Ludwigs University Freiburg, Germany

Abstract: In biomolecules, the transport of heat and vibrational energy occurs within (tens of) picoseconds. The propagation of conformational change in intramolecular signaling, on the other hand, is believed to occur on a much longer time scale of say, nano- to milliseconds. Interestingly, recent experiments and simulations indicate a possible connection between these fast and slow processes, e.g., via the notion that allosteric interactions may be of dynamical nature. To investigate these intriguing phenomena, transient infrared experiments on photoswitchable peptides and proteins are a powerful approach. Accompanying theses experimental studies, nonequilibrium molecular dynamics simulations allow us to study the mechanisms of energy transport and the transport of conformational change. We show that the energy flow in biomolecules is indeed fast and anisotropic, and can affect resides quite distant from the heat source. Transport of conformational change in a photoswitchable PDZ2 domain, on the other hand, is found to occur in various stages from pico- to microseconds, which may reflect elastic deformation, (de-)stabilized interactions and conformational transitions.