Dove Medical Press is pleased to invite you to submit your research to an upcoming Article Collection on "Bridging Bench to Bedside and Beyond: Advancing Sleep and Circadian Science for Precision Health Across All Ages", organized by Guest Advisors Dr. Azizi Seixas, Dr. Carolina Scaramutti and Dr. Mairead Moloney in Nature and Science of Sleep.

Sleep and circadian rhythms are fundamental to human health and well-being, influencing cognitive function, metabolic regulation, cardiovascular health, mental health, and immune function. Disruptions in sleep and circadian biology have been linked to a wide range of diseases, from neurodegenerative disorders and cardiometabolic conditions to mood disorders and impaired developmental trajectories in children. Yet, sleep and circadian health remain underutilized as modifiable targets in preventive medicine, clinical care, and public health initiatives. 

This Article Collection will focus on translational sleep and circadian health across the lifespan, highlighting research that spans developmental, clinical, and population health perspectives. We seek contributions that integrate basic science, clinical applications, and public health strategies to address sleep and circadian disruptions from infancy through older adulthood. The goal is to foster a lifespan approach to sleep health, identifying key windows for intervention, personalized treatment strategies, and innovative translational solutions that bridge laboratory research with real-world applications. 

From molecular insights into circadian rhythms to population-level interventions for sleep equity, this issue will showcase groundbreaking research that leverages multi-disciplinary methodologies, digital health tools, and precision medicine approaches to tackle sleep-related challenges at every stage of life. 

Understanding translational sleep and circadian health across the lifespan is critical for advancing precision medicine, public health, and clinical care. Sleep and circadian rhythms are foundational to nearly every aspect of human health—affecting brain function, cardiovascular health, metabolic regulation, immune response, and mental well-being. However, sleep remains underrecognized as a modifiable risk factor and is often excluded from mainstream healthcare strategies. 

This Article Collection will bridge the gap between basic science, clinical applications, and public health interventions, bringing together experts across neurology, psychiatry, cardiology, and digital health to explore novel, data-driven, technology-enhanced solutions for sleep-related disorders. By integrating AI, digital biomarkers, and multi-modal precision health approaches, this research will redefine sleep medicine and improve health outcomes across diverse populations and life stages. Ultimately, addressing sleep and circadian health inequities can lead to more effective, scalable, and personalized interventions, making healthcare more proactive, equitable, and transformative. 

Sleep and circadian health are critical yet underappreciated determinants of overall well-being, influencing neurodevelopment, cognitive aging, cardiometabolic health, mental health, and disease resilience across the lifespan. Advances in translational sleep research now offer unprecedented opportunities to integrate basic science, clinical medicine, public health, and digital health technologies to improve sleep-related outcomes for diverse populations. 

This Article Collection seeks cutting-edge contributions that bridge multiple disciplines, highlighting collaborative and interdisciplinary approaches to advancing sleep health. We encourage original research, systematic reviews, meta-analyses, and methodological papers exploring topics such as:

• Novel biomarkers & digital health tools for sleep and circadian rhythm assessment
• AI-driven and precision medicine approaches to sleep health interventions
• Cross-disciplinary research networks integrating neurology, psychiatry, cardiology, and public health
• Sleep inequities & social determinants of health in marginalized communities

By bringing together leading experts, this collection will advance the field toward equitable, scalable, and personalized sleep health solutions that can transform clinical and public health practices worldwide.

Keywords

• Translational Sleep Science
• Circadian Health
• Precision Sleep Medicine
• Interdisciplinary Sleep Research
• Digital and AI-Driven Sleep Technologies

All manuscripts submitted to this Article Collection will undergo desk assessment and peer review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are existing members of the Editorial Board. Please review the journal's Aims and Scope and author submission instructions prior to submitting a manuscript.

Please submit your manuscript through the Dovepress website. During submission, enter the promo code B71DF to indicate that your article should be considered for this Collection. Standard article publishing charges apply.

The manuscript submission deadline is 31 December 2025.

 

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Dove Medical Press is pleased to invite you to submit your research to an upcoming Article Collection on "Animal and Mathematical Models in Sleep Science and Sleep Medicine", in Nature and Science of Sleep.

Animal models are crucial for studying sleep and sleep disorders. They provide insights into the mechanisms of sleep regulation and the underlying causes of various sleep-related conditions, helping in the development of potential treatments. The previously used models include laboratory dogs, cats, rodents, zebrafish, fruit flies, and nematodes etc. These models have previously helped in understanding the mechanisms and in the development of new treatments for insomnia, restless legs syndrome, narcolepsy, and sleep apnea etc. The basic properties of the mechanisms regulating the sleep-wake cyclicity and behavior have easily lent themselves to mathematical modeling. Therefore, such modeling works together with experimental approaches to sleep research to provide a better understanding and prediction of findings in future studies of sleep regulation and sleep pathology. The two-process model of sleep-wake regulation (Daan et al, 1984) serves as an example of a successful story of mathematical modeling and model-based simulations in the field of sleep and biological rhythm research. This model has been the major contributor to our insights into the mechanisms underlying the 24-hour sleep-wake pattern for more than four decades.

Using animal models provides the following benefits: 1) help elucidate the brain areas, neural circuits, neurotransmitters involved in sleep regulation and sleep pathology; 2) environmental and genetic factors can be strictly controlled, allowing for the identification of specific causes and mechanisms of sleep and sleep disorders; 3) genetically modified models help to study the role of specific genes in sleep and sleep disorders; 4) used to test the efficacy and safety of new drugs for sleep disorders; 5) ethically justifiable than human studies, particularly when involving risky interventions and previously untested treatments. The mission of mathematical modeling includes: 1) to force a critical analysis of existing empirical datasets; 2) to enable the extraction of additional information from current datasets beyond what can be reported from common statistical analysis; 3) to allow more effective use of research resources; 4) to help in designing experimental protocols; 5) to provide accurate predictions of results in as-yet-untested conditions; 6) to point to hypothetical structures and processes that can be discovered in later experimental studies; 7) to uncover the underlying mechanisms and their basic components; 8) to give a common language to researchers studying not only sleep but also various other rhythmic phenomena in different species, organs, systems, and processes.

Sleep research has evolved from purely observational studies to sophisticated investigations employing animal models and mathematical frameworks. This Article Collection aims to showcase cutting-edge research that bridges experimental animal and human studies with computational approaches in sleep science and sleep medicine. Animal models have been instrumental in advancing our understanding of sleep regulation, circadian mechanisms, and sleep disorders. From rodent models of sleep apnea to non-human primate studies of circadian disruption, these approaches provide controlled experimental conditions impossible to achieve in human studies. Simultaneously, mathematical modeling has emerged as a powerful tool for understanding sleep homeostasis, predicting treatment outcomes, and analyzing complex sleep data. This Collection welcomes original research, reviews, and methodological papers covering in particular:

• Animal models of sleep disorders, including sleep apnea, insomnia, and circadian rhythm disorders
• Mathematical models of sleep regulation, including two-process models and circadian oscillators
• Translational studies bridging animal model findings to human sleep medicine
• Computational approaches to sleep stage scoring and sleep architecture analysis
• Machine learning applications in sleep medicine diagnosis and treatment
• Pharmacokinetic and pharmacodynamic modeling of sleep medications
• Network analysis of sleep-related brain circuits
• Predictive models for sleep disorder outcomes and treatment response

The Collection encourages submissions that demonstrate clear translational potential, methodological innovation, or novel insights into sleep mechanisms that could inform clinical practice.

Special Considerations

Given the technical nature of this collection, pls also consider:

• Requiring data availability statements for computational studies
• Encouraging submission of analysis code and mathematical model parameters
• Providing as Supplementary Materials the software allowing the model-based computations

All manuscripts submitted to this Article Collection will undergo desk assessment and peer review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are existing members of the Editorial Board. Please review the journal's Aims and Scope and author submission instructions prior to submitting a manuscript.

Please submit your manuscript through the Dovepress website. During submission, enter the promo code AF478 to indicate that your article should be considered for this Collection. Standard article publishing charges apply.

The manuscript submission deadline is 31 March 2026.

Please contact Catherine Teng at [email protected] with any queries regarding this Article Collection.

Guest Advisor

Arcady A. Putilov, Independent Research Group for Math-Modeling of Biomedical Systems, Berlin, Germany; Laboratory of Sleep/Wake Neurobiology, Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia

[email protected]

Dr. Arcady A. Putilov studies rhythmic phenomena in living nature and individual variation in the fields of chronophysiology, psychology, and psychiatry. He is the first and/or corresponding author in more than 95% of his published journal articles. Starting from 1991, he has served as a member of editorial board of Biological Rhythm Research and, since 2016, as a co-editor of this journal. He also serves as Section Editor-in-Chief for Clock&Sleep, Review Editor for Frontiers in Physiology, Assistant Editor for Frontiers in Network Physiology, and Consulting Editor for Nature and Science of Sleep.

 

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We are pleased to announce a new Article Collection in Nature and Science of Sleep, dedicated to the game-changing role of Continuous Positive Airway Pressure (CPAP) therapy in the management of obstructive sleep apnea (OSA). Since its clinical introduction, CPAP therapy has revolutionized patient care, offering significant benefits in improving sleep quality, reducing daytime fatigue, and enhancing overall cardiovascular health for eligible patients.

Given the importance of CPAP therapy in managing obstructive sleep apnea, Nature and Science of Sleep invites submissions of original research articles, reviews, and perspectives exploring the clinical efficacy, safety, mechanisms of action, and real-world application of these transformative therapies.

The Collection, edited by Editor-In-Chief Professor Ahmed BaHammam, is part of the new Game Changer series of Article Collections, focusing on breakthrough therapies, drugs, or technologies that have significantly altered the standard of care, leading to game-changing improvements in patient outcomes.

While the call is open to receive manuscripts across the broad spectrum of CPAP therapy in obstructive sleep apnea, the Editors are particularly interested in manuscripts relating to the following areas:
• Pathophysiological mechanisms of CPAP and alleviation of OSA symptoms
• Randomized controlled trials assessing the clinical effectiveness of CPAP therapy in OSA
• Observational studies examining the relationship between CPAP use and outcomes in the real-world setting.
• Studies focused on CPAP adherence and patient adherence
• Personalized CPAP approaches - Given the growing recognition that OSA treatment needs individualization beyond the traditional "one-size-fits-all" approach.
• Technology integration and telemedicine - The role of remote monitoring, mobile health applications, and digital therapeutics in improving CPAP adherence.
• Health economics and accessibility - Studies examining cost-effectiveness and strategies to improve access, particularly in developing countries where simpler, lower-cost CPAP devices show promise.
• Cardiovascular outcomes research - More robust studies addressing the ongoing debate about CPAP's cardiovascular benefits, particularly focusing on adherent patients.

Submitting authors will be eligible for a 20% discount on the Article Publishing charge by entering the code B2707. The code must be applied at the point of submission.

Papers published within the Game Changer series will benefit from additional promotional activities across Taylor and Francis, increasing the discoverability and visibility of your research.

Please review the journal's Aims and Scope and author submission instructions prior to submitting a manuscript. Please submit your manuscript through the Dovepress website. The manuscript submission deadline is 1 April 2026.

If you have any queries regarding the Article Collection or would like to discuss a submission, please email the Commissioning Editor at [email protected].

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We are pleased to announce a new Article Collection in Nature and Science of Sleep, focused on the role of orexin receptor antagonists in the management of insomnia.

Where behavioral interventions are not effective, pharmacological treatments can offer an alternative for insomnia patients. However, while benzodiazepines and "Z-drugs" can be effective in the short term, long-term use is associated with side effects including the development of tolerance and addiction. Orexin receptor antagonists, a relatively new class of medications, have reduced dependance and tolerance-inducing effects, showing promise for longer-term use.

Given the emerging importance of orexin receptor antagonists in managing insomnia, Nature and Science of Sleep invites submissions of original research articles, reviews, and perspectives exploring the clinical efficacy, safety, mechanisms of action, and real-world application of these therapies.

The Collection, edited by the Editor-In-Chief Professor Ahmed BaHammam, is part of the new Game Changer series of Article Collections, focusing on breakthrough therapies and drugs.

While the call is open to receive manuscripts across the broad spectrum of orexin receptor antagonists in insomnia, the Editors are particularly interested in manuscripts relating to the following areas:
• Studies exploring the neurobiological pathways and mechanisms through which orexin receptor antagonists exert their effects.
• Studies evaluating the efficacy of orexin receptor antagonists in different patient populations.
• Studies assessing the safety and tolerability of orexin receptor antagonists.
• Comorbid conditions - Studies examining orexin antagonists in patients with insomnia and concurrent sleep disorders or psychiatric conditions.
• Comparative effectiveness research - Head-to-head studies with other insomnia treatments.
• Long-term safety profiles - Extended follow-up studies given the relatively recent introduction of these medications.

Submitting authors will be eligible for a 20% discount on the Article Publishing charge by entering the code 20F21. The code must be applied at the point of submission.

Papers published within the Game Changer series will benefit from additional promotional activities across Taylor and Francis, increasing the discoverability and visibility of your research.

Please review the journal's Aims and Scope and author submission instructions prior to submitting a manuscript. Please submit your manuscript through the Dovepress website. The manuscript submission deadline is 1 April 2026.

If you have any queries regarding the Article Collection or would like to discuss a submission, please email the Commissioning Editor at [email protected].

View all papers in this article collection