Journal of Hepatocellular Carcinoma

El-Kassas M, Khalifa R, AlNaamani KM, Shousha H, Yilmaz Y, Sanai FM, Almattooq M, Labidi A, Akroush MWI, Debzi N, Abdelmalek MO, Abdeen NS, Tumi A, Elbadry M, El Fouly A, Marwan E, Al Suwaidi J, Elzouki AN, Alswat KA

Journal of Hepatocellular Carcinoma 2025, 12:1315-1335

Published Date: 8 July 2025

Original Research

Hyper-Relapse Disease is a Special Pattern of Relapse of Hepatocellular Carcinoma After Curative Hepatectomy: A Retrospective Cohort Study

Yang ZL, Gan YX, Xu JX, Tang YH, Ouyang LY, Qi LN, Xu L

Journal of Hepatocellular Carcinoma 2025, 12:1301-1314

Published Date: 5 July 2025

Original Research

Integrating CEUS Imaging Features and LI-RADS Classification for Postoperative Early Recurrence Prediction in Solitary Hepatocellular Carcinoma: A Machine Learning-Based Prognostic Approach

Liang L, Pang J, Zhang B, Que Q, Gao R, Wu Y, Peng J, Zhang W, Bai X, Wen R, He Y, Yang H

Journal of Hepatocellular Carcinoma 2025, 12:1287-1300

Published Date: 3 July 2025

Original Research

Retrospective Multicentre Real-Life Study Evaluating the Efficacy of Atezolizumab Combined with Bevacizumab for the Treatment of Metastatic Hepatocellular Carcinoma: HIREAL Study

Barbe-Richaud JB, Moinard-Butot F, Husson-Wetzel S, Bolliet M, Chiappa P, Belletier C, Ribeiro M, Poprawa E, Bigot C, Abergel A, Ben Abdelghani M

Journal of Hepatocellular Carcinoma 2025, 12:1279-1286

Published Date: 1 July 2025

Original Research

Combining Hepatic Arterial Interventional Therapies with Lenvatinib and Programmed Cell Death-1 Inhibitors for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Single-Center, Real-World Study

Shen X, Shao T, Yu J, Zhang Z

Journal of Hepatocellular Carcinoma 2025, 12:1267-1278

Published Date: 2 July 2025

Original Research

Preoperative Prediction of a Rare and Highly Aggressive Subtype of Hepatocellular Carcinoma Based on Multimodal Imaging and Clinical Indicators

Chen K, Zhu Y, Liu H, Deng M, Kong W, Wang W

Journal of Hepatocellular Carcinoma 2025, 12:1253-1266

Published Date: 30 June 2025

Original Research

Clinical Outcomes of AFP-Negative Patients with Advanced HCC: A Propensity-Matched Analysis from a Retrospective Cohort Study

Liu X, Zhuang L, Yang F, Liu P, Xia Z, Guo Y, Dong P, Chen C, Li Z

Journal of Hepatocellular Carcinoma 2025, 12:1241-1252

Published Date: 27 June 2025

Original Research

Comparison of Computed Tomography and Ultrasound-Guided Radiofrequency Ablation for Recurrent Subdiaphragmatic Hepatocellular Carcinoma After Resection

Liu HY, Hsiao CY, Hu RH, Liang PC, Wu CH

Journal of Hepatocellular Carcinoma 2025, 12:1231-1240

Published Date: 27 June 2025

Original Research

Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma

Chen PY, Chang CK, Chen BB, Hsu CH, Cheng AL, Shao YY

Journal of Hepatocellular Carcinoma 2025, 12:1221-1229

Published Date: 23 June 2025

Review

Application of Robotic Surgery in Hepatocellular Carcinoma

Li PH, Ding ZW, Ye YQ

Journal of Hepatocellular Carcinoma 2025, 12:1217-1220

Published Date: 19 June 2025

Original Research

Hepatic Arterial Infusion Chemotherapy Combined Apatinib/Camrelizumab for Recurrent Hepatocellular Carcinoma After Hepatectomy

Zheng X, Qian K

Journal of Hepatocellular Carcinoma 2025, 12:1205-1215

Published Date: 17 June 2025

Original Research

In Situ Vaccination with Poly-ICLC Combined with Systemic Nivolumab for the Treatment of Unresectable Hepatocellular Carcinoma

Liang JD, Liang PC, Shun CT, Chen CH, Wu YM, Hsu YC, Lee YT, Yang PM, Huang GT, Salazar AM, Lee HS, Sheu JC, Weng MT

Journal of Hepatocellular Carcinoma 2025, 12:1191-1204

Published Date: 14 June 2025

Original Research

Intravoxel Incoherent Motion Improves the Accuracy of Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma

Li M, Zhang G, Li J, Ren Y, Jin X, Ke Q, Guo C, Lv J, Lu H, Xu Y, Liang W, Quan X, Li X

Journal of Hepatocellular Carcinoma 2025, 12:1177-1190

Published Date: 11 June 2025

Original Research

Early Recurrence of Hepatocellular Carcinoma in Patients without Microscopic Vascular Invasion: Clinicopathological Characteristics and Risk Factors

Ngo HTT, Nguyen DD, Dang MX, Doan TTP, Thai TT

Journal of Hepatocellular Carcinoma 2025, 12:1167-1175

Published Date: 11 June 2025

Original Research

Genetic Variants of UGP2 and FBP2 in the Glycolysis Pathway Independently Predict Survival of Patients with HBV-Related Hepatocellular Carcinoma

Gong R, Qiu M, Liu Y, Cao J, Zhou Z, Lin Q, Jiang Y, Liang X, Wei Y, Wen Q, Chen P, Wei X, Wei J, Zhan S, Zhang R, Ye D, Yu H

Journal of Hepatocellular Carcinoma 2025, 12:1155-1166

Published Date: 7 June 2025

Original Research

Factor Analysis of the Effect of Hepatitis B-Related Liver Cancer Treatment Efficacy

Liu SW, Zhou Y, Feng XY, Hai L, Ma WL, Ma LN, Ding XC, Luo X

Journal of Hepatocellular Carcinoma 2025, 12:1141-1154

Published Date: 5 June 2025

Review

Radiomics and Deep Learning as Important Techniques of Artificial Intelligence — Diagnosing Perspectives in Cytokeratin 19 Positive Hepatocellular Carcinoma

Wang F, Yan C, Huang X, He J, Yang M, Xian D

Journal of Hepatocellular Carcinoma 2025, 12:1129-1140

Published Date: 5 June 2025

Original Research

Predicting Resistance and Survival of HCC Patients Post-HAIC: Based on Shapley Additive exPlanations and Machine Learning

Yao F, Miao J, Quan B, Li J, Tang B, Lu S, Yin X

Journal of Hepatocellular Carcinoma 2025, 12:1111-1128

Published Date: 31 May 2025

Original Research

Effectiveness and Safety of Systemic Therapy and Stereotactic Body Radiotherapy in Oligoprogressive and Oligometastatic Hepatocellular Carcinoma

Song Z, Zheng X, Wang H, Dong D, Zhu X, Geng J, Li S, Song M, Du R, Zhang Y, Liu Z, Cai Y, Li Y, Wang W

Journal of Hepatocellular Carcinoma 2025, 12:1097-1110

Published Date: 31 May 2025

Original Research

Intratumoral and Peritumoral Radiomics Based on DCE-MRI for Prediction of Microvascular Invasion Grading in Solitary Hepatocellular Carcinoma (≤3 cm)

Li Y, Li H, Feng Y, Lu L, Zhang J, Jia N

Journal of Hepatocellular Carcinoma 2025, 12:1083-1095

Published Date: 30 May 2025

Original Research

Spleen Volume Dynamics and Survival Outcomes in HCC Patients Undergoing Immune Checkpoint Inhibitors: A Retrospective Analysis

Fu X, Jiang S, Li Y, Guo Y, Gong B, Lou J, Li Y, Wang S, Sun Y, Ren Y, Chen Q, Yang L

Journal of Hepatocellular Carcinoma 2025, 12:1069-1082

Published Date: 30 May 2025

Original Research

Primary Prophylaxis for High-Risk Varices in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombus Delayed Hepatic Decompensation: A Retrospective, Propensity Score Matching Study

Chen YJ, Hou MC, Yang TC, Lee PC, Lu HS, Huang HC, Huang YH, Luo JC

Journal of Hepatocellular Carcinoma 2025, 12:1057-1067

Published Date: 28 May 2025

Clinical Trial Report

Adjuvant Lenvatinib for High-Risk CNLC IIb/IIIa Hepatocellular Carcinoma After Curative Hepatectomy: A Prospective Exploratory Study

Sun HC, Huang ZY, Wen T, Liu L, Zhu XD, Zhang E, Li C, Zhang X, Wang J, Fan J, Zhou J

Journal of Hepatocellular Carcinoma 2025, 12:1043-1056

Published Date: 22 May 2025

Original Research

Transarterial Chemoembolization, Molecular Targeted Treatments, and Programmed Death-(Ligand)1 Inhibitors, for Hepatocellular Carcinoma with Lung Metastasis: A Retrospective Cohort Study

Lu J, Chen X, Liu Y, Ding Y, Li B, Yang J, Peng W, Yang X

Journal of Hepatocellular Carcinoma 2025, 12:1031-1041

Published Date: 23 May 2025

Original Research

Combination of Hepatic Arterial Infusion Chemotherapy with Tyrosine Kinase Inhibitor Provides Better Survival in Advanced Hepatocellular Carcinoma Patients

Liu CW, Lin PT, Teng W, Chen WT, Su CW, Hsieh YC, Lin CC, Lin CY, Lin SM

Journal of Hepatocellular Carcinoma 2025, 12:1017-1029

Published Date: 21 May 2025

Original Research

Radiomics of Dynamic Contrast-Enhanced MRI for Predicting Radiation-Induced Hepatic Toxicity After Intensity Modulated Radiotherapy for Hepatocellular Carcinoma: A Machine Learning Predictive Model Based on the SHAP Methodology

Liu F, Chen L, Wu Q, Li L, Li J, Su T, Li J, Liang S, Qing L

Journal of Hepatocellular Carcinoma 2025, 12:999-1015

Published Date: 17 May 2025

Original Research

MRI Radiomics to Predict Early Treatment Response to TACE Combined with Lenvatinib Plus a PD-1 Inhibitor for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Lu D, Zhou L, Zuo Z, Zhang Z, Zheng X, Weng J, Yu Z, Ji J, Xia J

Journal of Hepatocellular Carcinoma 2025, 12:985-998

Published Date: 16 May 2025

Original Research

Atezolizumab Plus Bevacizumab Combined with or without Transarterial Chemoembolization in the Treatment of Advanced Hepatocellular Carcinoma: A Single-Center Retrospective Study

Li J, Bai Y, Xiong F, Liu X, Hu J, Zhang G, Liu J, Wu S, Zheng C, Kan X

Journal of Hepatocellular Carcinoma 2025, 12:973-984

Published Date: 15 May 2025

Original Research

The Real-World Prevalence of Esophagogastric Varices, Bleeding, Emergency Room Visits, and Hospitalization Among Patients with Advanced Hepatocellular Carcinoma in the United States: A Retrospective Cohort Study

Parikh ND, Park NJ, Locker M, Chopra I, Yeaw J, Yu S

Journal of Hepatocellular Carcinoma 2025, 12:961-972

Published Date: 15 May 2025

Original Research

Can Intra-Operative Ablation-Specific Features Based on Ultrasound Fusion Imaging be Used to Predict Early Recurrence of Hepatocellular Carcinoma After Microwave Ablation: A Proof-of-Concept Study

Kang H, Liu Z, Huang B, Liang S, Yang K, Liu H, Lu M, Yan R, Chen X, Xu E

Journal of Hepatocellular Carcinoma 2025, 12:949-960

Published Date: 12 May 2025

Original Research

Machine Learning Radiomics for Predicting Response to MR-Guided Radiotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter Cohort Study

Su K, Liu X, Zeng YC, Xu J, Li H, Wang H, Du S, Wang H, Yue J, Yin Y, Li Z

Journal of Hepatocellular Carcinoma 2025, 12:933-947

Published Date: 9 May 2025

Original Research

Decoding ARF4 and EIF5B-Based Prognostic Signatures and Immune Landscape Following Insufficient Radiofrequency Ablation in Hepatocellular Carcinoma: Through Multi-Omics and Experimental Validation

Zhang Y, Lu Y, Zheng S, Luo W, Tan M, Luo B

Journal of Hepatocellular Carcinoma 2025, 12:909-931

Published Date: 9 May 2025

Original Research

NRF1-Induced lncRNA DDX11-AS1 Contributes to the Progression of Hepatocellular Carcinoma via Activating CA9 Expression and the MEK/ERK Pathway

Li Y, Shi M, Bie B, Tian H, Li J, Li Z, Sun J

Journal of Hepatocellular Carcinoma 2025, 12:891-908

Published Date: 7 May 2025

Original Research

Effectiveness of Minimally Invasive Hepatectomy in Patients with Early or Intermediate-Stage Hepatocellular Carcinoma: A Multi-Institutional Cohort Study in an Asian Population

Chen HK, Chang KC, Shao SC, Soong RS, Chen YC, Wu CF, Wu TH, Chou TS, Chan SC, Lai ECC

Journal of Hepatocellular Carcinoma 2025, 12:879-890

Published Date: 7 May 2025

Original Research

Post-TACE ALBI-Score Trajectory in Intermediate and Advanced Hepatocellular Carcinoma: Prognostic Implications and Influencing Factors Analysis

Li J, Feng T, Cui C, Wang H, Su T, Jin L, Zhao X, Xiao W

Journal of Hepatocellular Carcinoma 2025, 12:865-878

Published Date: 5 May 2025

Original Research

Prognostic Significance of Elevated Platelet Count (>200 x 10^9 per L) in BCLC Stages B and C of Hepatocellular Carcinoma: A Retrospective Multicenter Analysis

Munker S, Rodriguez I, Bernhart K, Ben Khaled N, Findik M, Siegmund LK, Ye L, Reiter FP, Roessler D, Nasseh D, Balcar L, Pomej K, Scheiner B, Weiss C, Pinter M, Seidensticker M, Mayerle J, Philipp AB, De Toni EN

Journal of Hepatocellular Carcinoma 2025, 12:855-864

Published Date: 5 May 2025

Review